Domperidone can be used in the form of tablets or as domperidone suppositories. The active ingredient of these tablets and suppositories is domperidone, which belongs to a group of drugs called dopamine antagonist. This drug is used against sickness and several other stomach problems, such as abdomen bloating, reflux and stomach fullness and it has the role to block dopamine receptors that are to be found in the upper part of the digestive system. Because of that, the muscles at the entry to the stomach become tightened, while those at the exit of the stomach become relaxed. All this leads to the quick passage of food through the stomach. Thus, vomiting, sickness, bloating, and fullness are prevented. Domperidone also blocks the dopamine receptors in an area in the brain and prevents nausea messages from reaching to the vomiting center, thus decreasing the feeling of nausea and preventing vomiting.
Uses of domperidone
This drug is used to treat nausea and vomiting in adults, but in children as well. Furthermore, it reduces the stomach bloating, fullness and reflux in adults. One who takes this medicine must know that domperidone suppositories are just for renal use and they are not taken by mouth. Furthermore, it is better to take them before the meals. Domperidone should not be used if a person suffers from the pituitary gland cancer, reduced liver function, lactose intolerance, glucose/galactose malabsorption or galactosemia. A doctor must be informed about these conditions, but also if a person is allergic to some of the domperidone ingredients. Although the side effects of this medicine are not established regarding pregnancy and breastfeeding, it is still recommended to avoid domperidone in these conditions, unless a doctor says it is necessary.
Side effects of domperidone
Domperidone has side effects, like most drugs, and they may appear or not. One of the side effects of this drug is hyperprolactinemia, which is the medical term for high level of prolactin in the blood. This condition may further lead to gynecomastia, which is breast enlargement in men, stopping of menstruation in women, and excessive production of breast milk in men and women. Rarely, domperidone causes lack of sexual interest in men.
Other side effects include abdominal cramps, diarrhea, allergy and urticaria. In some cases even uncontrolled movements of the hands, legs, face, eyes, neck or tongue or stiffness have been reported. If any of these side effects appear, it is important to stop using this medicine and visit a doctor who will decide whether to lower the dosage or to replace domperidone with some other drug.