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Zuclopenthixol (Zuclopentixol,Cisordinol, Clopixol, Acuphase) is an antipsychotic drug used to treat psychotic episodes, especially schizophrenia.

The medication is blocking many receptors in the brain, including dopamine receptors, which controls behavior and mood. Schizophrenia and other psychotic illnesses are caused by the excessive dopamine activity in the brain. Blocking the dopamine receptors the drug is controlling psychotic illnesses, calming the patients and easing aggression and hallucinations.

Possible side effects of zuclopenthixol are tremor and rigidity of hands, legs or face. Sometimes, patients experience anxiety, agitation and drowsiness.

The medication could induce a serious condition known as tardive dyskinesia, with the rhythmical movements of the whole face or parts of the face (tongue, mouth and jaw) and sometimes unconscious moves of the arms andlegs.

Neuroleptic malignant syndrome is a rare and severe side effect. High temperature, pale face, sweating and a fast heartbeat are the symptoms of this condition, and if it happens the drug should be stopped instantly.

Oculogyric crisis is another serious side effect, which seeks immediate medical attention. The condition is presented with uncontrolled rolling of the eyes and neck.

Zuclopenthixol affects the heart, increasing heart beat and heart rate and causing low blood pressure.

The drug is showing effects to the nervous system. Patients are complaining about headaches, insomnia or nightmares, and memory and speech problems.

Older patients have problem with the body temperature and abnormal sweating. Their body is reflecting the temperature of the outside, so they could easily suffer form the heat stroke during summer and hypothermia during cold weather.

Gastrointestinal side effects include nausea, vomiting, constipation, indigestion. Problems with urine are not rare, along with increased salivation or dry mouth. Patients report weight and appetite changes and sexualproblems.

Other reported side effects include: eye problems, skin reactions, seizures, hyperprolactinaemia (high levels of milk producing hormone, prolactin), blood related problems (most likely problems with white blood cells), and possible liver problems.

Make sure to inform your doctor about every other medication or remedy you have been using, for zuclopenthixol treatment may interfere with them and lead to some serious side effects.

It is important not to drive or operate any machinery while on zuclopenthixol therapy, because the drug may cause vision problems and sleepiness.

Alcohol should be avoided for it could enhance sleepiness.

Any abnormal movements of the face should be reported to the doctor immediately, to check for possible tardive dyskinesia.

Inform you doctor about high fever, excessive sweating, drowsiness and stiff muscles, because these symptoms may indicate neuroleptic malignant syndrome.

The medication should be used as doctor prescribed it. Do not stop taking the drug even if you are feeling better, because the symptoms will come back. The doctor will decide if and how to stop the use of zuclopenthixol.

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