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Magnesium oxide side effects

Information on Magnesium Oxide

Magnesium oxide is an antacid which is commonly used for the treatment of constipation, indigestion and similar digestion problems, due to its very potent acidity and laxative properties. Magnesium oxide may sometimes be associated with the occurrence of certain side effects. Some people may experience no side effects at all, while other may experience minor or sometimes even severe side effects. The most common side effect which is commonly associated with the use of magnesium oxide is diarrhea. If a person experiences any of the severe side effects after using magnesium oxide, immediate medical attention must be sought. Severe side effects of magnesium oxide may or may not include vomiting, rash, slow reflexes, nausea, itching, tarry stools, difficulty breathing, swelling of the tongue, tightness in the chest, swelling of the lips, swelling of the mouth and swelling of the face. Hypermagnesemia is also commonly affiliated with the use of magnesium oxide. Mild instances of this medical condition are usually tolerable, but severe and even moderate instances of hypermagnesemia may affect the cardiovascular and nervous system.

Side Effects of Magnesium Oxide

Gastrointestinal side effects of magnesium oxide include diarrhea and magnesium toxicity, while there have also been certain rare cases which included paralytic ileus. Magnesium oxide is known for suppressing the neuromuscular junction and the neuromuscular transmission. The levels of serum magnesium usually determine the severity of these side effects. Mild increase of the levels may result in sedation, decreased tendon reflexes, mental confusion and muscle weakness. Moderate increase of the levels may result in a low blood pressure and slower respiratory rate. Severe changes of the levels usually trigger respiratory paralysis, coma, mental depression and areflexia. Some cases may even be ended by death. The most common cardiovascular side effects of magnesium oxide include bradyarrhythmia, depressed myocardial conductivity and hypotension. Peripheral vasodilation commonly triggers all the cardiovascular effects of magnesium oxide. Cardiotoxicity and asystole may also be present in certain rare cases. Renal insufficiency, digitalis therapy, acidosis, hyperkalemia and hypocalcemia all increase the risk of the occurrence of the aforementioned side effects. Suppressed release of the parathyroid hormone combined with renal tubular absorption of magnesium and calcium may be held responsible for the occurrence of hypocalcemia. These side effects may be complicated even further and result in hypercalciuria and a decreased reabsorption of calcium. These medical conditions actually aggravate the hypocalcemia, which is the most common metabolic side effect of magnesium oxide.

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