Testosterone injections dosage

Testosterone Injections

Testosterone is the male sexual hormone primarily synthesized in the testes of men and female ovaries. Small quantities of this hormone are also secreted by the adrenal glands of both men and women. In men, testosterone is responsible for secondary male characteristics, including facial hair, bone mass, muscle growth and deep voice. There is an extremely high rise in testosterone level in puberty, which is correlated with the rapid growth in boys at that age.

In adults, testosterone effects are more prominent in women. It affects general energy level and libido and maintains cardiovascular health. It is also proven that testosterone regulates platelet aggregation and affects the brain and many of its functions.

Testosterone can be used as supplemental therapy in people suffering from the low production of body testosterone, as a treatment for some diseases in the elderly and also as a supplement to increase libido. Bodybuilders also use this hormone, to increase muscle growth.

The peak of testosterone production is at the age of 30 in men. If some of these people suffer from a low sex drive, there is a possibility to use testosterone injections to improve the condition. These injections can also be used in people suffering from andropause or diabetes mellitus type 2.

Testosterone is also used in women, as a treatment for low libido, tiredness and bone weakening. Menopausal and women who had their ovaries removed also suffer from low levels of testosterone and may benefit from testosterone injections.

Dosage

The dosage of testosterone injections depends on the age, gender and symptoms of a patient, but in all cases, they must be administered or supervised by a doctor. An unadjusted dose of testosterone can cause several adverse effects, including male acne and gynecomastia, and hoarse voice and facial hair in females.

There are two types of testosterone injections: enanthate and cypionate testosterone injections. The most commonly used for regular people are enanthate testosterone injections, but athletes and bodybuilders frequently use cypionate.

The proper dose of testosterone injections is about 500 mg per week, but it may vary from 50 to 500 mg, and be given once or two times a week.

Fifty-one young (aged 19–35 yr) and 52 older (aged 59–75 yr) men completed treatment with monthly injections of a GnRH agonist plus randomly assigned weekly doses of testosterone enanthate (25, 50, 125, 300, or 600 mg) for 5 months.

During testosterone administration, total and free E2 levels increased dose-dependently (dose effect, P
Total and free E2 levels and E2:T ratios during T administration were higher in older than young men, but age-related differences in free E2 and free E2:T ratios were not significant after adjusting for testosterone levels, percentage fat mass, and SHBG. DHT levels and DHT:T ratios were dose-related but did not differ between young and older men.
Mechanistic modeling of free hormone data revealed that the conversions of T to E2 and DHT were both consistent with saturable Michaelis-Menten kinetics. The in vivo Km values were estimated to be 1.83 nm for aromatase and 3.35 nm for 5?-reductase, independent of age. The Vmax parameter for E2 was 40% higher in older men than younger men, but Vmax for DHT was not significantly different between age groups.
In men in whom endogenous testicular steroidogenesis has been suppressed by administration of GnRH agonist, the steady-state circulating E2 concentrations during testosterone administration should reflect the ratio of E2 production from peripheral aromatization of testosterone and plasma E2 clearance (as discussed in Appendix A). Although differences in SHBG levels may contribute to altered clearance rates, the observation that the free E2 levels are also higher in older men is consistent with an increase in whole body aromatization.
Anecdotally, high doses of testosterone and other androgens have been reported to be associated with gynecomastia. Our data indicate that the occurrence of gynecomastia with high doses of testosterone cannot be explained on the basis of high estradiol to testosterone ratios; however, the high levels of E2 attained at high doses may be sufficient to account for it.

✓ Fact confirmed: The Effects of Injected Testosterone Dose and Age on the Conversion of Testosterone to Estradiol and Dihydrotestosterone in Young and Older Men Kishore M. Lakshman, Beth Kaplan, Thomas G. Travison, Shehzad Basaria, Philip E. Knapp, Atam B. Singh, Michael P. LaValley, Norman A. Mazer,a and Shalender Bhasina; 2010 Jun 9.

Bodybuilders are known to think that more testosterone is always better and to use even 1 or 2g of testosterone every week. Doctors claim that these high doses of testosterone may cause gynecomastia and other side effects, and recommend 400 to 800 mg of this hormone for men who want to increase their body mass.