Solpadol medicine consists of paracetamol and codeine phosphate, and it is used as a pain reliever. There is an assumption that it brings down the quantity of prostaglandins in the brain and spinal cord. Prostaglandin is a substance that increases in our body when some kind of trauma happens, and paracetamol lowers the level of prostaglandin, so even though the trauma exists, we are not in that much pain.
Another ingredient of Solpadol is codeine, which has more effect in relieving pain than paracetamol. Codeine imitates the function of neurotransmitters in our body known as endorphins, and it prevents sensations of pain from getting to our centers in the brain. Due to that, we don’t feel pain.
Side Effects
Solpadol can cause some adverse effects, and there will be named some of the most common ones, but you should be aware that not every person has to experience them. The usual problems that the usage of Solpadol causes are the difficult evacuation of the bowels, the feeling of sickness which can be followed by throwing up, vertigo, problems while urinating, disarray, slowed pulse, and others.
These are not all of the side effects of Solpadol usage, but if you wish to find out more about this medication, please contact your medical advisor or read the leaflet that comes with the medication.
You should inform your medical advisor about the other medications that you are using, no matter where you bought them, which means that you have to mention those bought over the counter or in an herbal store. This is significant because of the possible interactions with Solpadol since some medications could interact with Solpadol.
The doctor will know if the medicines that you are using can be combined with Solpadol. You shouldn’t use this medicine if you are already using other medicines that contain paracetamol, because you may pass the daily limit of paracetamol intake. This medicine should be used with attention in those who were using antidepressants, so-called MAO inhibitors during the last two weeks.
Those who take Cholestyramine should be careful not to use it about an hour after the usage of paracetamol. There is a danger for those who use paracetamol for a long period of time, that, if bleeding occurs, it will be difficult to stop it because paracetamol inhibits coagulation. Solpadol is more likely to cause sleepiness in combination with other medicines such as antipsychotics, barbiturates, benzodiazepines, opioids, and tricyclic antidepressants.
- A total of 42,849 IDO presentations to 37 of the 40 hospitals EDs operating in Ireland in 2003-2008 were recorded according to standardised procedures. Data on sales of paracetamol-containing drugs to retail pharmacies for the period 1998-2008 were obtained from IMS Health.
- The withdrawal of distalgesic from the Irish market resulted in an immediate reduction in sales to retail pharmacies from 40 million tablets in 2005 to 500,000 tablets in 2006 while there was a 48% increase in sales of other prescription compound analgesics. The rate of IDO presentations to hospital involving distalgesic in 2006-2008 was 84% lower than in the three years before it was withdrawn (10.0 per 100,000).
- There was a 44% increase in the rate of IDO presentations involving other prescription compound analgesics but the magnitude of this rate increase was five times smaller than the magnitude of the decrease in distalgesic-related IDO presentations. There was a decreasing trend in the rate of presentations involving any paracetamol-containing drug that began in the years before the distalgesic withdrawal.
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