Kenalog 10 is an injection containing syntheticglucocorticoid corticosteroids and has very strong anti-inflammatoryproperties. It is suitable only for intra-articular and intralesional use.Kenalog 10 is a sterile aqueous suspension and it contains triamcinoloneacetonide, sodium chloride, benzyl alcohol, carboxymethylcellulose sodium andpolysorbate. Hydrochloric acid or sodium hydroxide can sometimes be added tofinely adjust the pH balance. The air inside the injection is always replacedby nitrogen.
Kenalog 10 can sometimes trigger some side effects due toone or more of its ingredients. Benzyl alcohol can sometimes cause metabolicacidosis, hypotension and kernicterus. In some infants the injection has beenfatal because of excessive amounts of benzyl alcohol. The main problem lies in thefact that it is impossible to determine the exact amount of benzyl alcohol atwhich the toxicity occurs. Kenalog 10 is a suspension so intravenousadministration is not recommended and it has to be applied using strict aseptictechnique. There have also been certain rare cases of anaphylactoid reactionsreported. Kenalog 10 is a long-acting preparation so it cannot be used in thesituations of acute stress. High doses of Kenalog 10 cannot be used for thetreatment of traumatic brain injuries.
Kenalog 10 is known for sometimes causing an increase inblood pressure, water and salt retention and it also sometimes increases theexcretion of potassium as well. These side effects are usually associated withthe use of synthetic derivatives. Excretion of calcium is always a common thingduring the treatment with Kenalog 10. The patient may require potassium andcalcium supplements during the treatment and daily intake of salt should besignificantly restricted. There have also been rare cases where Kenalog 10caused myocardial infarctions and ruptures of the left ventricular free wall.All types of steroids commonly cause an insufficiency in glucocorticosteroidsafter the treatment and they can also sometimes produce certain reversible typeof HPA axis suppression. Some patients may require dosage adjustments due tothe changes in the thyroid status.
During the corticosteroid treatment, a person becomes moresusceptible to various types of infections, even more than healthyindividuals. The ability to localizeinfections and the resistance get significantly decreased. The infection may becaused by virtually any type of pathogen and it can be mild or severe in itsnature. Other side effects include protein cabolism, hyperglycemia, skinatrophy, folliculitis, dermatitis, skin burning, itching and irritation.