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Bendroflumethiazide (bendrofluazide) is a thiazidediuretic medication. The medication is mostlyused in hypertension therapy. It works by inhibiting the absorption of salt andwater in the part of kidneys called renal tubules (distal convoluted tubule or DCT) but the exact mechanism is still unknown.

Caution

Bendroflumethiazide should not be used if you are allergicto the medication or any containing substance or any sulfonamide medication. Donot use this medication if you have been already using dofetilide or ketanserin,or have problems urinating.Inform your doctor about any medicine you have been using,including OTC and herbal preparations. All allergies must be reported to yourdoctor kidney and liver issues, diabetes, asthma, parathyroid problems,high levels of cholesterol or lipids, gout or low blood pressure. If you arepregnant, plan to become pregnant or breastfeeding, consults the doctor beforeyou start using bendroflumethiazide.Low levels of sodium (natrium), kalium (potassium), magnesium or chloride andhigh levels of calcium should be reported to the doctor.

Possible side effects

The drug is affecting the metabolism, leading tohyperuricemia and hypercalciemia and hypophosphatemia and hypomagnesiemia. Thesemetabolic changes are common side effects and usually appear in daily dosesover 100mg.

This medication can be responsible for some gastrointestinalproblems, like nausea, vomiting, diarrhea, constipation, abdominal pain, anorexiaand gastric irritation, and rarely for cholecystitis, jaundice pancreatitis.

Patients report mild cases of dizziness, tiredness or sometimesheadache and muscle pain.

Bendroflumethiazide could cause decrease tolerance of glucoseand bad effect to lipids in the blood, mostly affecting patients with risks ofdiabetes and coronary artery disease.

Some patients treated with this medication experienceorthostatic hypotension and syncope which could lead to temporary vision lossin patients with glaucoma problems.

Dermatological problems may appear in people hypersensitiveto bendroflumethiazide and include rare cases of hair loss, erythema multitforme, Stevens-Johnsonsyndrome and exfoliative dermatitis. Allergic reactions are expected inpatients allergic to sulfonamides.

Blood issues are rare. Bendroflumethiazide could cause aplasticand hemolytic anemia and thrombocytopenia.

Kidney problems in bendroflumethiazide therapy may be thereason to decrease the dose or stop the treatment.

Interactions with other medications

Bendroflumethiazide may interact with many other medicinesand increase their or its own adverse effects. Be careful and inform yourdoctor if you are using: NSAID (non steroid anti-inflammatory medications), barbiturates,corticosteroids, corticotropin, narcotic pain killers, highblood pressure medications, diazoxide, nondepolarizing muscle relaxants, lithium, digoxin,dofetilide, ketanserin, and insulin or diabetes drugs.

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