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Tinzaparin isthe blood thinning (anti-coagulant) medication that belongs to the group of lowmolecular weight heparin (LMWH). As all other LMWH, tinzaparin is used forprevention of blood clots and the treatment of deep vein thrombosis (DVT) andpulmonary embolism (blood clots in the lungs).

It is usuallygiven subcutaneously or in some cases intravenously.

Side Effects

The mostcommon tinzaparin side effects include hematologic problems. There are reports ofpatients experiencing hemorrhage, hematoma, thrombocytopenia, epistaxis,hematuria and anemia. Many different bleedings and blood-related problems werealso associated with the use of this medication.

Heparin-inducedthrombocytopenia (HIT) may be present in patients using unfractioned heparin orLMWHs, and could lead to transient ischemic attack, skin necrosis, thrombosis,gangrene or stroke. Women, especially non-white, with lower body weight or withthrombocytopenia, are at greater risk of developing this condition.

Patients usingtinzaparin might also experience heart and chest problems: chest pain, hypo orhyper-tension, angina pectoris, tachycardia, etc. Some patients reported pulmonaryembolism or liver problems while using this drug.

There mightbe present some headache, fever, nausea, vomiting, digestion difficulties, andalso some back pain in these patients. Tinzaparin also affects the centralnervous system and may induce dizziness and confusion.

Skin problemsare present at the injection spot and people complained about hematoma, abscess,cellulitis and skin necrosis. Some of the patients using tinzaparin experiencedrash, pruritus, urticaria or ischemic necrosis.


Patients usingtinzaparin while having some other medical condition might bleed easily. Thisinclude: bleeding diseases, poorly controlled hypertension, abdominal bleeding,kidney or liver problems, amyloidosis or infection of the heart lining. Recentsurgical procedures, especially eye, brain or spine surgeries might also causethe same unwanted effect.

There is apossibility of severe blood clots in the brain or spinal cord, if you are usingtinzaparin. This potential complication is emphasized in patients who hadrecent epidural anesthesia, lumbar puncture (spinal tap), spinal surgery orgenetic spinal defect. Other blood thinners, Aspirin and NSAIDs (non steroidalanti-inflammatory drugs) also have the same adverse effect.


Many drugsinterfere with tinzaparin, so make sure to inform your doctor and pharmacistabout all medications, OTC drugs and remedies you have been using.

Peopleallergic tinzaparin or any other substance in the drug should not use it. Ifyou had an allergic reaction to heparin, benzyl alcohol, sulfites or porkproducts do not use this drug.

Patients withthe history of low platelet count or those with active bleeding also shouldn’tuse tinzaparin.

This medicationmay be responsible for some non-specified neoplasms.

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