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Tramadol, marketed as Zydol, comes in the form ofinjections, capsules, and soluble tablets. Its active ingredient tramadolhydrochloride makes it an opioid painkiller. These painkillers imitate the effects of endorphins whichare naturally found in the body and are known to reduce pain. In addition,tramadol affects the neurotransmitters which carry signals to nerve cells, thus providing relief from pain. Being a powerful painkiller, Zydol is used to relievemoderate to extreme pain.

Side effects

Not all individuals are affected by the possible sideeffects of the medicine in the same way. Some people may have side effectsother than those listed here, or may not experience any side effects at all.

Common side effects of Zydol use include dizziness,headache, drowsiness, sweating, pain in the abdominal region, diarrhea, nausea,vomiting or constipation, dry mouth, blurred vision, mood swings, confusion, nightmares,palpitations, increased heart rate, drop in the blood pressure, hallucinations,respiratory depression, difficulty urinating, weakness in the muscles, rash anditching.

Interactions withother medicines

Taking Zydol at the same time as bupropion, SSRI andtricyclic antidepressants, antipsychotic medication and mefloquine, increasesthe risk of seizures. Zydol’s active ingredient tramadol amplifies the anti-bloodclotting action of warfarin and other anticoagulants.


People taking Zydol SR tablets are advised against drinkingalcohol, driving and operating machinery, as the medicine can cause drowsiness. This medicine is also not suitable for children under theage of 12, and individuals with malfunctioning kidneys. Due to the presence oflactose, the medicine is not recommended to people with galactose intolerance,glucose-galactose malabsorbtion or the Lapp lactase deficiency.

Rare cases of withdrawal symptoms have been reported afterthe discontinuous use of the medicine. Affected individuals experiencednervousness, agitation, anxiety and sleeplessness, which lasted only for a fewdays.

Elderly people, people with reduced kidney or liverfunctions, persons suffering from asthma or respiratory depression, individualswith elevated brain pressure, decreased blood flow to vital organs, convulsions,epilepsy, history of drug abuse and head injury are advised to use thismedicine with caution.

This medicine is not to be used during pregnancy andbreastfeeding, in cases of uncontrolled epilepsy, alcohol or drug abuse, orallergy to its components. Zydol tablets should not be used if the person istaking sleeping pills or tranquilizers such as benzodiazepines or barbiturates,other painkillers affecting the brain, sedating antihistamines, and MAOIantidepressant.

People with the conditions listed above, and those taking anykind of medication, should talk to their doctor before taking Zydol.

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