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Tramadol, marketed as Zydol, comes in the form of injections, capsules, and soluble tablets. Its active ingredient tramadol hydrochloride makes it an opioid painkiller. These painkillers imitate the effects of endorphins which are naturally found in the body and are known to reduce pain. In addition, tramadol affects the neurotransmitters which carry signals to nerve cells, thus providing relief from pain. Being a powerful painkiller, Zydol is used to relieve moderate to extreme pain.

Side effects

Not all individuals are affected by the possible side effects of the medicine in the same way. Some people may have side effects other than those listed here, or may not experience any side effects at all.

Common side effects of Zydol use include dizziness, headache, drowsiness, sweating, pain in the abdominal region, diarrhea, nausea, vomiting or constipation, dry mouth, blurred vision, mood swings, confusion, nightmares, palpitations, increased heart rate, drop in the blood pressure, hallucinations, respiratory depression, difficulty urinating, weakness in the muscles, rash and itching.

Interactions with other medicines

Taking Zydol at the same time as bupropion, SSRI and tricyclic antidepressants, antipsychotic medication and mefloquine, increases the risk of seizures. Zydol’s active ingredient tramadol amplifies the anti-blood clotting action of warfarin and other anticoagulants.


People taking Zydol SR tablets are advised against drinking alcohol, driving and operating machinery, as the medicine can cause drowsiness. This medicine is also not suitable for children under the age of 12, and individuals with malfunctioning kidneys. Due to the presence of lactose, the medicine is not recommended to people with galactose intolerance, glucose-galactose malabsorbtion or the Lapp lactase deficiency.

Rare cases of withdrawal symptoms have been reported after the discontinuous use of the medicine. Affected individuals experienced nervousness, agitation, anxiety and sleeplessness, which lasted only for a fewdays.

Elderly people, people with reduced kidney or liver functions, persons suffering from asthma or respiratory depression, individuals with elevated brain pressure, decreased blood flow to vital organs, convulsions, epilepsy, history of drug abuse and head injury are advised to use this medicine with caution.

This medicine is not to be used during pregnancy and breastfeeding, in cases of uncontrolled epilepsy, alcohol or drug abuse, or allergy to its components. Zydol tablets should not be used if the person is taking sleeping pills or tranquilizers such as benzodiazepines or barbiturates, other painkillers affecting the brain, sedating antihistamines, and MAOI antidepressant.

People with the conditions listed above, and those taking any kind of medication, should talk to their doctor before taking Zydol.

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