Side effects of pyrazinamide

Pyrazinamide

Pyrazinamide is the medicine which is antibiotic and which is used for the treatment of tuberculosis. The drug is largely bacteriostatic, but can be bactericidal on actively replicating tuberculosis bacteria.

Side effects of Pyrazinamide

Like most drugs, pyrazinamide may have undesirable effects. These side effects may appear or not, and their influence depends and vary from person to person. It is always important to consult the doctor before starting to use any drugs including pyrazinamide. The doctor must be informed if the person uses some other drugs in order to prescribe the proper dose of this drug, because its effectiveness may be increased or reduced when it is consumed in the combination whit some other remedies.

It is crucial to inform the doctor if suffering from liver or heart disease, diabetes mellitus, if the patient has some problems with gout, or is allergic to pyrazinamide. It is also recommended not to use it while pregnant or while breastfeeding the baby because the effects of this drug on the new-born child are not yet known.

The most frequent of all adverse effects of pyrazinamide is artaglaria, the medical term for the pain in the joints. This pain is never so strong or unendurable, so the patients usually continues to take this drug as a medicine to treat their illness. Pain in the joints is sometimes stressful but never harmful for the patient. Of cardiovascular side effects, acute hypertension may appear. Furthermore, nausea and vomiting, as well as jaundice and malaise are hepatic side effects that can appear when the person consumes pyrazinamide. Moreover, granulomatous hepatitis is not quite common but may also occur. Fever, chills, and great fatigue are some of the effects of this medicine.

One of the most serious side effects of pyrazinamide is hepatotoxicity. This adverse effect is usually differently experienced and depends on the doses of this medicine which is taken in. It is quite common that the doctor will give the patient a test to check thedosage. Some allergic skin reactions, such as skin rash or itching may occur, as well as urticaria, pruritus, skin pigmentation, desquamation, and photosensitivity.

Anorexia and anemia are quite frequent adverse side effects of this drug. In addition to the side effects of pyrazinamide that have been mentioned so far, disuria, hyperuricemia, as well as interstitial nephritis are renal adverse effects which are reported by the consumers of this medicine. It is very important to visit the doctor if some of these side effects appear.