Dasatinib (Sprycel) is a cancer medication used to slow the cancer growth and stop potentialmetastasis. It is used to treat some forms of leukemia, such as CML (chronic myeloidleukemia), ALL (acute lymphoblastic leukemia) if all the other cancertreatments weren’t effective. Sometimes dasatinib is used to treat metastatic melanoma.
Reported sideeffects of dasatinib includes fever, tiredness, abdominal and other kinds ofpain. It is possible to experience discomfort, high temperature or edema, asthenia,dizziness, weight loss or weigh gain, abdominal distension and some chest pain.
The most common sideeffects connected to the use of dasatinib are hematological problems. More than70% of the patients report neutropenia, thrombocytopenia, pancytopenia andanemia. Bleeding, coaglulopathy and aplasia of red blood cells are rare. Use of dasatinib might lead to increased riskof infection in general.
Diarrhea is presentin 50% of patients on dasatinib, as well as dyspepsia, dysphagia, gastritis andcolitis. Nausea, vomiting, intestinal bleeding, constipation and some other gastrointestinalproblems are less frequent.
1/3 of all dasatinibpatients suffer from shortness of breath and cough, asthma and pneumonitis. Lessoften, patients report respiratory infection, pneumonia or pulmonary edema, andsometimes bronchospasm and acute respiratory distress syndrome.
Psychiatric sideeffects are common, such as insomnia, anxiety or depression, confusion and sometimesweakened libido. Possible effects on the nervous systems are also headaches, sleepiness,syncope, dysgeusia (changed sense of taste), tremor and convulsions. Sometimes dasatinibmay affect the brain causing amnesia, neuropathy, bleeding in the brain, cerebrovascularcondition ischemic attack or leukoencelopathy.
The medicationaffects the cardiovascular system, causing arrhythmia, changes in bloodpressure, flushing and palpitations, angina pectoris, cardiomegaly, myocarditis,pericarditis, infarction, congestive heart failure and many other heartproblems.
Pain in the musclesand joints, inflammation, stiffness and weakness of the muscles are frequentlyconnected to the use of dasatinib. Cases of rhabdomyolysis are rare.
Skin rash is verycommon, in many different forms, and patients have reported dry skin, hair loss,acne, urticaria and dermatitis. Some other dermatological issues are rare, aswell as allergic reactions.
Dasatinib affect themetabolism of phosphates and calcium, causing their blood levels to drop. Levelsof liver enzymes (ALT, AST, transaminase) and bilirubin are increased in some ofthe patients. The medication may affect the kidneys, causing increase ofcreatinine or renal failure.
Use of dasatinib mayprovoke gynecomastia, or affect the menstruation.
Dasatinib oftenaffects the eyes, causing visual problems, conjunctivitis or dry eyes.
Although dasatinibis an anti cancer drug, it does have certain tumor potential, and there havebeen cases of tumor lysis syndrome.