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Sumatriptan belongs to the group of medications called triptans,used to treat the migraine. Triptans are serotonin (or 5-HT1) receptor agonists. Theymimic the effects of serotonin and narrow the blood vessels in the brain,relieving the migraine pain.

Sumatriptan is a medication used in treatment of the migrainewithout the early signs of migraine attack. Those “signs” are called aura, andoften include vision problems, like dark spots, flashing light or linesaffecting the vision. This drug may also be used to treat cluster headaches.

Adverse Effects

The most common side effects include: nausea, vomiting, musclecramps, diarrhea and weakness. Some patients had rectal bleeding and Xerostomia.Many patients experience dizziness, sleepiness,flushing and burning and tingling feeling.

When using thesumatriptan as injection, people report changes on the injection spot, usuallyredness, swelling and burning sensation, but sometimes even changes insubcutaneous fat tissue (such as lipoatrophy or lipohypertrophy).

Chest problems are quite frequently reported by patients usingsumatriptan. The tightness, heaviness and pressureinthe chest, or chest pains, are usually associatedwith the anxiety attack in these patients, although some specialists considerthis symptom as a sign of cardiac ischemia.

Some of the cardiovascular effects might be severe, including lifeendangering arrhythmias, Prinzmetal angina pectoris or myocardial infarction.

Sumatriptan affects the blood and may cause anemia, pancytopenia, thrombocytopeniaand cyanosis.

Some of the patientsare hypersensitive to the medication. They might experience rash, redness of theskin or breathing problems, such as fast or uneven breathing, or evenbronchospasm. Changes in face skin color, swellingof the eyes, eyelids, face and lips are reported. Hypersensitivity is rarely a serious conditionwhen using sumatriptan. Sumatriptan mightcause oversensitivity to the sun and sunburns.

Sumatriptan might affect the liver and kidneys, causing liver problems,acute kidney failure or angioneurotic edema.

Some patients experience vision problems when using this drug. Blindness,caused by sumatriptan temporary or permanent is extremely rare condition.

This medication often causes nervous side effects. The most common aredizziness, headache and paresthesias, but there were cases of serotoninsyndrome, vasculitis, cerebrvascular problems and subarachnoid hemorrhage. Convulsionsare rarely reported. However, patients having problems with epileptic attacksor some other forms of seizures should be especially careful when usingsumatriptan. Psychiatric side effectsmight include anxiety and panic disorders.

Sumatriptan may cause the increase of growth hormone levels in theblood.


Sumatriptan should not be used in patient with coronary arterydisease.

Patients with prior history of seizures, pregnant women and breastfeeding moms should consult their doctor about the use of this medication.

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