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Creatinine in the organism

Creatinineis a molecule that is produced in the muscles, by the metabolicprocesses in their cells. It can be regarded as metabolic waste. Itis a result of metabolizing creatine, an important molecule forproduction of energy in the muscles. Typically, some two percent ofcreatine present in our bodies gets converted to creatinine every 24hours. As is typical for most of metabolic waste, creatinine istransported to the kidneys by the bloodstream, and most of it isfiltered out and disposed of in the urine.

Creatininelevels are usually constant on a day-to-day basis, as they arerelated to muscle mass, which remains constant when observed in suchshort time periods.

Importanceof creatinine levels checking

Asamount of creatine that is secreted daily is basically constant, itcan serve as a good indicator of kidney function. If there is anyproblem with the function of the kidneys, levels of creatinine willrise, and such irregularly high levels indicate that there is somekidney damaging process ongoing. For this reason, standard tests ofblood and urine include creatinine level check. More accurate testscalculate the amount of creatinine that is filtered by the kidneys.

Howmuch creatinine is normal?

Foradult males, normal levels of creatinine range from 0.6 to 1.2milligrams (mg) per deciliter (dl), and from 0.5 - 1.1 milligramsper deciliter for adult females.

Adultsthat are more muscular have proportionally larger amount ofcreatinine than is average, while the elderly may have lower thanaverage creatinine levels. Malnutritioned people, people whoexperienced severe weight loss or a long-lasting ilness might alsohave below average creatinine levels as they have low muscle mass.

Personswith just one kidney have normal levels that range from 1,8 to 1,9mg/dl.

Creatininelevels from 10 or higher in adults or 2 and higher in infants areassociated with serious problems of kidney function and such personswill need a regular treatment with dialysis machine to purify theirblood.


Howthe body will react to excess creatinine depends on amount on excesscreatinine. Typical symptoms of excess creatinine (that is, impairedkidney function) are fatigue, loss of appetite, and fever, togetherwith dehydration, low amount of produced urine, swelling in the limbsand headaches. These symptoms are common for more conditions, soremember that they could indicate some other problem as well.

Treatmentand prevention

Avoidtoo many foods rich with protein in your diet, drink lots of fluids,reduce intake of caffeine and alcohol, and monitor your sugar levels.These changes in routine can make the difference. Also, monitor yourcreatinine levels regularly.

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