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Creatinine Clearance

Creatinine is a metabolic product of creatine. After metabolicreactions, creatine gets transformed into creatinine and acts as the fuel thatbrings energy necessary for contraction of the muscles. Creatinine is consideredthe waste product and as such kidneys are responsible for its excretion inurine.

There are no special preparations for creatinine clearancetest, but the doctor might recommend fasting before the test for several hours. Testwill use your urine and blood samples and determine the level of creatinine for24 hours. Because of that, the sample you bring to the lab should be sample ofyour urine produced throughout last 24 hours.

Creatinine Clearance Test Results

Creatinine clearance test is made to determine the level ofcreatinine in the urine, comparing it to the creatinine level in the blood. If thetest reveals increased level of creatinine it means that there is something wrongwith the kidneys. Because of that, this creatinine clearance test is used to detectkidney and other problems in the human body. Doctors find this test very usefulin patients suffering from kidney and cardiovascular diseases, since these medicalproblems might also affect the proper functioning of the kidneys. The test isalso used to establish the rate of filtration of all other toxic substances throughthe kidneys.

Normal level of creatinine is around 0.6 and 1.2 mg/dL.

If your creatinine level is lower than 0.6 mg/dL it mightindicate that you don’t eat enough protein, or perhaps that your muscles arenot big and strong as they should be, because of the muscular dystrophy. Age andother medical conditions, including pregnancy can also affect and decrease thelevel of creatinine in the urine and blood. Sometimes, there is no reason toworry. If you drink plenty of water, it can also affect the level of creatinineand lower it significantly.

Creatinine level higher than 1.2 mg/dL is the sign of kidneyproblems. Elevated creatinine points to serious condition caused by kidney failure.In some cases, patients with high level of creatinine could suspect on kidneycancer.

Normal creatinine levels in the blood are about 100 to 140ml/min for men and 90 to 130 ml/min for women. These numbers are then used tocalculate estimated glomerular filtration rate (eGFR), which should be between95 and 125 ml/min.

If the results of the test are lower than 65 ml/min itindicates the kidney problem, and the values under 20 ml/min point to kidneyfailure. Pregnant women might experience increase of eGFR.

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