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Estradiol is a sex hormone which is predominant in women; however, men also have the hormone as well, thought at much lower levels. The hormone also represents the major estrogen in human beings and is responsible for reproductive and sexual functions and affects certain organs and the bones as well. When a woman is of reproductive age, estradiol is produced by the ovaries and smaller amounts are made by the adrenal cortex and testes in the male. In women, estradiol is responsible for the growth of reproductive organs, supports the lining of the vagina, cervical glands and endometrium, which lines the uterus and fallopian tubes.

During a woman's menstrual cycle is produced by the follicles and stimulates ovulation, without it a couple trying to conceive may not be able to do so. During pregnancy, estradiol production is increased because of the placenta and blocks estrogen production which could lead to a miscarriage. Estradiol (oestradiol) levels in men and women both need to be present in the right levels or it can create a hormonal imbalance which may lead to fertility impairment. The effect that estradiol has on male reproduction is complicated, it is made in the Sertoli cells in the testicles, and medical research suggests that it is vital to the survival of male sperm cells. Scientific studies have also note that a decline in sperm count may be attributed to low levels of estradiol as well, which could lead to male infertility if not treated.

When a couple has been trying to conceive a baby for more than a year and has been unsuccessful, it may be time to consider visiting a fertility specialist. Through a consultation and evaluation, a physician can determine whether or not one of the individuals has low levels of estradiol and determine if the problem is causing fertility impairment. There are many ways in which to treat and manage low estradiol levels such as via an oral medication, topical, injectable or vaginal preparation. Estradiol (oestradiol) levels in men and women play a vital role in many different functions of the human body. Without adequate levels of the hormone, certain reproductive functions can be impaired to the point where fertility suffers. When trying to have a baby for a long period of time with no results, it may be worthwhile for a couple to both be tested to ensure adequate levels of this most important hormone.

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