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Majordepression is also commonly known under the names of major depressive disorder,clinical disorder, or just depression. This disorder affects the mind, as wellas the body. It is a chronic disease, which has negative effects on theperson’s thinking, feeling, and behavior. The most common symptoms ofmajor depression are the feelings of sadness, hopelessness, anxiety,frustration, and agitation. Furthermore, decreased concentration, slowerthinking and speaking, the lack of sexual drive, as well as fatigue, tiredness,insomnia or excessive sleeping may also appear. In addition to these signs,during the depression, the person sometimes has the feelings of guilt or worthlessness.What is most serious when this disorder is in the question, is that somepersons even have suicidal thoughts and frequently consider their own death. Insuch cases it is crucial to immediately call someone who is quite confident, beit a friend, a family member, or a doctor.

As forthe causes of the major depression, biological differences, neurotransmitters,hormones, inherited traits, stresses life events, and early childhoodtrauma are usually considered to be the major causes for this disorder. Majordepression requires proper treatment throughout the whole life, even in theperiods when the person who suffers from this disorder feels better.

Majordepression is usually treated with antidepressants. There are six classes ofantidepressant: selective serotonin reuptake inhibitors, serotonin andnorepinephirine reuptake inhibitors, norepinephrine and dopamine reuptakeinhibitors, atypical antidepressants, tricyclic antidepressants, and monoamineoxidase inhibitors. At the beginning of the treatment, the doctors usuallyprescribe selective serotonin reuptake inhibitors, because they have themildest side effects, such as decreased sexual interest and, in some cases,headache, restlessness, insomnia, and digestive problems. The most effectivedrugs of this kind are fluoxetine, paroxetine, citalopram, sertraline, andescitalopram. Duloxetine, venlafaxine and desvenlafaxine are the most usedmedications of the serotonin and norepinephrine reuptake inhibitors class,which can cause sweating and dizziness as the side effects. Of all thenorepinephrine and dopamine reuptake inhibitors, the doctors usually recommendbupropion that in some cases it increases the risks of the seizuresappearance. Trazodone and mirtazapine are two typical antidepressantsthat are usually taken in the evening and improves sleeping. Tricyclicantidepressants tend to be avoided because they have many negative and seriousside effects, such as low blood pressure, dry mouth, blurred vision,constipation, confusion, urinary retention, and the gaining of the weight.

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