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Metronidazole

Metronidazole (Flagyl) is an antibiotic, antiprotozoal andamebicide medication, used to fight the infections in your body. It is found especiallypotent fighting anaerobic bacteria, such as Clostridium difficile.

Metronidazole is used in the treatments of bacterial infectionsof the vagina, respiratory infections, joints and stomach. Sometimes, this drugis used to treat skin problems, such as rosacea or fungating tumors.

Caution

Use metronidazole exactly as it was prescribed by yourdoctor. Do not end the therapy before the infection get completely cured, evenif you feel better after some time.

This medication should not be used to treat vaginal yeastinfection or viral infection like common cold or flu.

Side Effects

You should not drink alcohol while using metronidazole. Avoidalcohol for minimum 3 days after the treatment, because it may cause redness orwarmth of the skin, nausea, vomiting and speed the heartbeat. The reaction ofmetronidazole with alcohol is known as disulfiram-like reaction.

Intravenous application of metronidazole could causethrombophlebitis. The possibility of this condition is usually minimized byintravenous catheters.

Metronidazole most serious side effects are peripheral andoptic neuropathy, which patients feel as paresthesias and numbness of the legs.The condition might be persistent and is usually associated with long termtreatment with high doses of oral metronidazole. Patients are advised to stopthe treatment if these symptoms occur, but neuropathy might be persistent.

Also, patients experience other nervous system side effects,such as convulsions, encephalopathy and aseptic meningitis. Some patientsreported headaches, vertigo, ataxia, weakness, sleeping problems and confusion,rarely agitation or hallucinations. There were also cases of dentate nucleiabnormalities, causing ataxia and dysarthria. The symptoms disappear once themetronidazole was stopped.

People udin metronidazole may suffer from depression, anxietyor weaken libido.

Common gastrointestinal side effects include nausea,vomiting, abdominal problems, dry mouth and unpleasant taste on the tongue,epigastric problems and constipation. Use of metronidazole might cause Candidaovergrowth, leading to infection and inflammation of the tongue, stomach andvagina. Rarely, there were cases of pseudomembranous colitis and pancreatitis,caused by metronidazole treatment.

Fever and darkened urine are also known as side effects ormetronidazole use.

Metronidazole can affect the genitourinary tract, leading todisyria, polyuria, incontinence and vaginal itching and candidiasis.

This drug might cause reversible cases of neutropenia andthrombocytopenia.

Patients have reported hypersensitivity to metronidazole,followed by urticaria, pruritus, rash, flushing, fever, Stevens-Johnsonsyndrome or nasal congestion. Cases of serum sickness-like reaction were rarelyreported.

Patients suffering from Crohn’s disease and treated with highdoses of metronidazole for long periods of time may develop breast or coloncancers.

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