Duodenal ulcers are sores that are present in the proximal part of small intestines which is called duodenum. The majority of causes lead to formation of duodenal ulcers. Apart from stress and inappropriate diet and life style duodenal ulcers may develop due to usage of the certain medications. Ulcers may be additionally caused by certain infective agents among which Helicobacter pylori is most significant. After the exact cause is found a patient may be treated properly.
Causes of Duodenal Ulcers
Aspirin is additional contributor to duodenal ulcers. It is administered in coagulopathies. Still if Aspirin is used with proton pump inhibitors the damage to the duodenum can be successfully evaded.
- Helicobacter Pylori
- Idiopathic Duodenal Ulcers
- Life Style
- Genetic Predisposition
- Other Causes
Duodenal ulcers may form even as a consequence of certain infections. For example Epstein-Barr virus or cytomegalovirus can be related to duodenal ulcers.
Chemotherapy is known to increase the production of stomach acid. Certain chemotherapeutics such as 5-fluorouracil or methotrexate drastically increase the risk of duodenal ulcers. Even radiation therapy can lead to damage of the mucous membrane of duodenum leading to ulcers.
And finally, drug addicts that use crack cocaine are at higher risk of developing duodenal ulcers as this drug leads to Vasoconstriction in majority of tissues. This way even duodenum is affected and low supply of blood leads to damage of the mucous membrane and consequent forming of ulcers.